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doi: 10.1523/JNEUROSCI.0115-14.2014 [DOI] [PMC free article] [PubMed] [Google Scholar] 157.Antonsen KK, Klausen MK, Brunchmann AS, et al

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Summary of REDEFINE 1 and REDEFINE 2 trials with CagriSema, presented this week at #ADA2025 and published in NEJM: REDEFINE 1: 3,417 participants with obesity or overweight (without diabetes) treated with CagriSema achieved a 22.7% weight loss after 68 weeks, compared to 2.3% with placebo 40.4% of participants on CagriSema achieved a weight loss of 25% or more The weight loss was slightly below the company's initial expectations of at least 25% REDEFINE 2: 1,206 participants with obesity or overweight and type 2 diabetes treated with CagriSema achieved a 15.7% weight loss after 68 weeks, best in the category thus far , compared to 3.1% with placebo 89.7% of participants achieved a weight loss of 5% or more Mean HbA1c reduction of 2.07% Article links: nejm.org/doi/full/10.10 nejm.org/doi/full/10.10 Summary of REDEFINE 1 and REDEFINE 2 trials with CagriSema, presented this week at #ADA2025 and published in NEJM: REDEFINE 1: 3,417 participants with obesity or overweight (without diabetes) treated with CagriSema achieved a 22.7% weight loss after 68 weeks, compared to 2.3% with placebo 40.4% of participants on CagriSema achieved a weight loss of 25% or more The weight loss was slightly below the company's initial expectations of at least 25% REDEFINE 2: 1,206 participants with obesity or overweight and type 2 diabetes treated with CagriSema achieved a 15.7% weight loss after 68 weeks, best in the category thus far , compared to 3.1% with placebo 89.7% of participants achieved a weight loss of 5% or more Mean HbA1c reduction of 2.07% Article links: nejm.org/doi/full/10.10 nejm.org/doi/full/10.10 Hopefully primary prevention in normal weight is next Pharma has obesity in its sights

This sudden spike can overwhelm the body's ability to process alcohol, raising the risk of overdose